| Result | Offense | Defense | Week | Date | Opponent | W/L | Score | Total (yd) | Pass (yd) | Rush (yd) | 1st Downs | TO's | Total (yd) | Pass (yd) | Rush (yd) | 1st Downs | TO's |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 09/09/2012 | @ Denver Broncos | L | 19 - 31 | 284 | 209 | 75 | 19 | 1 | 334 | 240 | 94 | 20 | 1 |
| 2 | 09/16/2012 | New York Jets | W | 27 - 10 | 331 | 265 | 66 | 21 | 0 | 219 | 129 | 90 | 16 | 1 |
| 3 | 09/23/2012 | @ Oakland Raiders | L | 31 - 34 | 433 | 379 | 54 | 24 | 2 | 321 | 202 | 119 | 21 | 1 |
| 4 | 09/30/2012 | Bye Week | ||||||||||||
| 5 | 10/07/2012 | Philadelphia Eagles | W | 16 - 14 | 343 | 207 | 136 | 22 | 0 | 246 | 168 | 78 | 19 | 2 |
| 6 | 10/11/2012 | @ Tennessee Titans | L | 23 - 26 | 412 | 356 | 56 | 19 | 1 | 359 | 265 | 94 | 21 | 1 |
| 7 | 10/21/2012 | @ Cincinnati Bengals | W | 24 - 17 | 431 | 264 | 167 | 22 | 2 | 185 | 105 | 80 | 11 | 1 |
| 8 | 10/28/2012 | Washington Redskins | W | 27 - 12 | 355 | 215 | 140 | 25 | 0 | 255 | 169 | 86 | 17 | 0 |
| 9 | 11/04/2012 | @ New York Giants | W | 24 - 20 | 349 | 191 | 158 | 22 | 2 | 182 | 114 | 68 | 13 | 1 |
| 10 | 11/12/2012 | Kansas City Chiefs | W | 16 - 13 | 249 | 154 | 95 | 14 | 1 | 290 | 148 | 142 | 14 | 1 |
| 11 | 11/18/2012 | Baltimore Ravens | L | 10 - 13 | 311 | 177 | 134 | 17 | 3 | 200 | 153 | 47 | 12 | 0 |
| 12 | 11/25/2012 | @ Cleveland Browns | L | 14 - 20 | 242 | 193 | 49 | 13 | 8 | 238 | 130 | 108 | 14 | 1 |
| 13 | 12/02/2012 | @ Baltimore Ravens | W | 23 - 20 | 366 | 270 | 96 | 19 | 3 | 288 | 177 | 111 | 19 | 2 |
| 14 | 12/09/2012 | San Diego Chargers | L | 24 - 34 | 340 | 271 | 69 | 18 | 2 | 294 | 200 | 94 | 19 | 0 |
| 15 | 12/16/2012 | @ Dallas Cowboys | L | 24 - 27 | 388 | 319 | 69 | 20 | 2 | 415 | 328 | 87 | 23 | 1 |
| 16 | 12/23/2012 | Cincinnati Bengals | L | 10 - 13 | 280 | 185 | 95 | 15 | 3 | 267 | 253 | 14 | 16 | 3 |
| 17 | 12/30/2012 | Cleveland Browns | W | 24 - 10 | 212 | 121 | 91 | 17 | 0 | 320 | 182 | 138 | 18 | 4 |